Andre Iguodala had 14 points and 12 rebounds for the Sixers, who have won the last three games after losing Game 1.
Holiday stretched the lead with consecutive 3-pointers late in the game to put the Sixers one win away from joining the short list of eighth-seeded teams that have won a series against a No. 1 seed.
Game 5 is Tuesday in Chicago.
In NBA postseason history, the eighth seed has won a first-round series against the No. 1 seed four times, including last season when Memphis eliminated San Antonio. Golden State (2007), New York (1999) and Denver (1994) also pulled off the rare feat.
The Sixers won three straight playoff games for the first time since Allen Iversonfueled their run to the 2001 NBA finals.
Holiday was sensational down the stretch after a rocky first 3 1/2 quarters. He missed his first five 3-point attempts until he nailed one to make it 77-73. He hit another the next time down for a seven-point lead to the delight of a roaring sellout crowd.
The undermanned Bulls kept at it and refused to use playing without their two biggest impact players as an excuse. C.J. Watson, who scored 17 points, hit a step-back jumper to make it a two-point game.
In a whistle-happy game, Holiday went to the line with 51 seconds left and made both for an 84-80 lead.
Suddenly — and shockingly — the Sixers are a win away from taking a playoff series for the first time since 2003.
Iguodala played through right Achilles’ tendinitis to make so many impact plays for the Sixers.
Without a full roster, the Bulls barked at the refs, talked trash on the court and used every self-motivational tactic they knew to gain an edge on the Sixers.
Noah took charge on the bench as head cheerleader. Wearing a protective walking boot, he clapped, cheered and offered instruction in the timeout huddle. Noah was needed more on the court than as a de facto assistant coach.
Noah was injured midway through the third quarter of Game 3 when he stepped on Andre Iguodala’s foot driving the lane and crashed to the court. Noah instantly grabbed his left ankle in pain. Bulls coach Tom Thibodeau said Noah felt better Sunday.
Boozer actively did his best to keep the Bulls in the game. He played through foul trouble to score 18 points through three quarters (matching his combined total for the first two games) and he fought for some of the tough rebounds Noah would grab.
It wasn’t enough.
Iguodala stopped a Bulls run in the third with a 3 for a 57-56 lead. Bad leg and all, he still soared for a thunderous dunk on the break in the first half for an eight-point lead. One of the worst fourth-quarter foul shooters in the NBA, Iguodala even made both with 26.6 seconds left.
Game 4 lacked the electric atmosphere early that accompanies a postseason game because the 10-mile Broad Street Run was routed in front of the sports complex. The Wells Fargo Center was barely half full by tip and the announced crowd of 20,142 needed time to warm up.
By the time Holiday hit his 3s, the arena was going wild.
His sharp shooting in clutch time came at the right time after a slow start.
Holiday and Evan Turner continue to befuddle coach Doug Collins with their inconsistency. The under-25 starting backcourt followed a solid Game 3 with a combined 3 for 22 for eight points in the first half. Lou Williams, perhaps the league’s top reserve, failed to bail them out with a 1-for-6 effort in the half. Their struggles were a key reason the depleted Bulls kept the score tight even without their two stars.
The Sixers crashed the boards early without Noah in the lineup and had 15 second-chance points in the half to grab a 10-point lead.
Hawes hit the go-ahead 20-footer late in the fourth for the Game 3 winner and he continued his hot hand into Sunday. He had made seven of his first eight shots, including a 3-pointer right before the second quarter buzzer to send the Sixers into halftime with 44-42 lead.
Boxer Bernard Hopkins, former NBA great Dolph Schayes, former Sixers great Julius Erving and actor Bill Murray attended the game. … Philadelphia last won a playoff series when it beat New Orleans in 2003. … The Sixers hold a 3-1 lead in a best-of-seven series for the first time since the 1984 East semifinals.
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